منابع مشابه
Gene-centered regulatory networks.
Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators. In the past years, significant progress has been...
متن کاملGene-centered regulatory network mapping.
The Caenorhabditis elegans hermaphrodite is a complex multicellular animal that is composed of 959 somatic cells. The C. elegans genome contains ∼20,000 protein-coding genes, 940 of which encode regulatory transcription factors (TFs). In addition, the worm genome encodes more than 100 microRNAs and many other regulatory RNA and protein molecules. Most C. elegans genes are subject to regulatory ...
متن کاملGene Regulatory Networks
Tryptophan is one of the 20 amino acids that link together to form proteins. For humans it is an essential amino acid, we must get it from our diet since we cannot synthesize it. E. coli bacterial cells, however, can synthesize the amino acid tryptophan when it is not provided from the environment (e.g. the gut where it lives). It would be wasteful to synthesize tryptophan when it is readily av...
متن کاملAdaptive gene regulatory networks
Regulatory interactions between genes show a large amount of cross-species variability, even when the underlying functions are conserved: there are many ways to achieve the same function. Here we investigate the ability of regulatory networks to reproduce given expression levels within a simple model of gene regulation. We find an exponentially large space of regulatory networks compatible with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Briefings in Functional Genomics
سال: 2009
ISSN: 2041-2649,2041-2657
DOI: 10.1093/bfgp/elp049